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Title
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Incorporation of hexose nucleoside analogs into oligonucleotides - synthesis, base-pairing properties and enzymatic stability
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Author
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Abstract
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| Oligonucleotides containing 1-(2,4-dideoxy-beta-D-erythrohexo-pyranosyl)thymine (2) and 1-(3,4-dideoxy-beta-D-erythrohexo-pyranosyl)thymine (3) were synthesized on a solid support using the phosphoramidite approach. The properties of these oligonucleotides were compared with the earlier reported characteristics of oligonucleotides containing 1-(2,3-dideoxy-beta-D-erythrohexo-pyranosyl)thymine (1). The order in enzymatic stability of end-substituted oligonucleotides is 3 > 1 much greater than 2. The hybridization properties of the modified oligonucleotides are in reverse order: 2 much greater than 1 > 3. |
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Language
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English
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Source (journal)
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Nucleic acids research. - London
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Publication
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London
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1992
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ISSN
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0305-1048
1362-4962
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DOI
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10.1093/NAR/20.18.4711
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Volume/pages
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20
:18
(1992)
, p. 4711-4716
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ISI
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A1992JR35400003
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Full text (Publisher's DOI)
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