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Publication
Title
The complexity of the receptor shapes unique pharmacological profiles
Author
Abstract
Gamma-amino butyric acid (GABA) is the most abundant inhibitory neurotransmitter in the central nervous system (CNS) and many physiological actions are modulated by GABAA receptors. These chloride channels can be opened by GABA and are a target for a variety of important drugs such as benzodiazepines, barbiturates, neuroactive steroids, convulsants and anaesthetics. GABAA receptors are involved in anxiety, feeding and drinking behaviour, circadian rhythm, cognition, vigilance, and learning and memory. Moreover, deficits in the functional expression of GABAA receptors have been implicated in multiple neurological and psychiatric diseases. This review aims to discuss the unique physiological and pharmacological properties of the multitude of GABAA receptor subtypes present in the CNS, making this receptor an important target for novel rational drug therapy.
Language
English
Source (journal)
Drug discovery today. - London
Publication
London : 2009
ISSN
1359-6446
DOI
10.1016/J.DRUDIS.2009.06.009
Volume/pages
14 :17/18 (2009) , p. 866-875
ISI
000270199100008
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier c:irua:79735
Creation 05.01.2010
Last edited 10.12.2024
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