Title
Characterization of **Trypanosoma brucei gambiense** variant surface glycoprotein LiTat 1.5 Characterization of **Trypanosoma brucei gambiense** variant surface glycoprotein LiTat 1.5
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Subject
Chemistry
Biology
Human medicine
Source (journal)
Genetics and Molecular Research
Volume/pages
11(2012) :2 , p. 1260-1265
ISSN
1676-5680
ISI
000305519600049
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement of the native VSGs by recombinant proteins or synthetic peptides, the sequence of VSG LiTat 1.5 was derived from cDNA and direct N-terminal amino acid sequencing. Characterization of the VSG based on cysteine distribution in the amino acid sequence revealed an unusual cysteine pattern identical to that of VSG Kinu 1 of T. b. brucei. Even though both VSGs lack the third of four conserved cysteines typical for type A N-terminal domains, they can be classified as type A.
E-info
https://repository.uantwerpen.be/docman/iruaauth/cf137b/0292560.pdf
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