Title
Antibacterial, antifungal and cytotoxic activities of two flavonoids from **Retama raetam** flowers Antibacterial, antifungal and cytotoxic activities of two flavonoids from **Retama raetam** flowers
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Bazel ,
Subject
Chemistry
Source (journal)
Molecules: a journal of synthetic chemistry and natural product chemistry. - Bazel
Volume/pages
17(2012) :6 , p. 7284-7293
ISSN
1420-3049
ISI
000305800400076
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81-15.62 mu g/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 mu g/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/4feaab/2569.pdf
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