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Title
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Antibacterial, antifungal and cytotoxic activities of two flavonoids from **Retama raetam** flowers
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Author
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Abstract
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| We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81-15.62 mu g/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 mu g/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens. |
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Language
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English
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Source (journal)
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Molecules: a journal of synthetic chemistry and natural product chemistry. - Bazel
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Publication
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Bazel
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2012
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ISSN
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1420-3049
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DOI
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10.3390/MOLECULES17067284
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Volume/pages
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17
:6
(2012)
, p. 7284-7293
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ISI
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000305800400076
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Full text (Publisher's DOI)
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Full text (open access)
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