| Title |
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Antibacterial, antifungal and cytotoxic activities of two flavonoids from **Retama raetam** flowers
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| Author |
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| Abstract |
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| We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81-15.62 mu g/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 mu g/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens. |
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| Language |
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English
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| Source (journal) |
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Molecules: a journal of synthetic chemistry and natural product chemistry. - Bazel |
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| Publication |
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Bazel : 2012
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| ISSN |
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1420-3049
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| Volume/pages |
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17:6(2012), p. 7284-7293
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| ISI |
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000305800400076
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| Full text (Publisher's DOI) |
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| Full text (open access) |
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