Title
Control of proliferation, endoreduplication and differentiation by the **Arabidopsis E2Fa-DPa transcription factorControl of proliferation, endoreduplication and differentiation by the **Arabidopsis E2Fa-DPa transcription factor
Author
Faculty/Department
Faculty of Sciences. Biology
Research group
Molecular Plant Physiology and Biotechnology
Publication type
article
Publication
Heidelberg,
Subject
Biology
Source (journal)
The EMBO journal. - Heidelberg, 1982, currens
Volume/pages
21(2002):6, p. 1360-1368
ISSN
0261-4189
1460-2075
ISI
000174398900012
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
New plant cells arise at the meristems, where they divide a few times before they leave the cell-cycle program and start to differentiate. Here we show that the E2FaDPa transcription factor of Arabidopsis thaliana is a key regulator determining the proliferative status of plant cells. Ectopic expression of E2Fa induced sustained cell proliferation in normally differentiated cotyledon and hypocotyl cells. The phenotype was enhanced strongly by the co-expression of E2Fa with its dimerization partner, DPa. In endoreduplicating cells, E2FaDPa also caused extra DNA replication that was correlated with transcriptional induction of S phase genes. Because E2FaDPa transgenic plants arrested early in development, we argue that controlled exit of the cell cycle is a prerequisite for normal plant development.
E-info
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