Title
Therapeutic strategies to deplete macrophages in atherosclerotic plaquesTherapeutic strategies to deplete macrophages in atherosclerotic plaques
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Research group
Physiopharmacology (PHAR)
Publication type
article
Publication
London,
Subject
Pharmacology. Therapy
Source (journal)
British journal of clinical pharmacology. - London
Volume/pages
74(2012):2, p. 246-263
ISSN
0306-5251
ISI
000306220100004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Macrophages can be found in all stages of atherosclerosis and are major contributors of atherosclerotic plaque development, progression and destabilization. Continuous recruitment of monocytes drives this chronic inflammatory disease, which can be intervened by several strategies: reducing the inflammatory stimulus by lowering circulating lipids and promoting cholesterol efflux from plaque, direct and indirect targeting of adhesion molecules and chemokines involved in monocyte adhesion and transmigration and inducing macrophage death in atherosclerotic plaques in combination with anti-inflammatory drugs. This review discusses the outlined strategies to deplete macrophages from atherosclerotic plaques to promote plaque stabilization.
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