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Title
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Maternal mumps antibodies in a cohort of children up to the age of 1 year
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Author
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Abstract
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| The duration of the presence of maternal mumps antibodies in a prospective cohort study is presented. Immunoglobulin G against mumps was portioned with a commercial ELISA test (EuroimmunA (R) anti-mumps Virus AT ELISA, Germany) on samples from 213 mother-child pairs at seven time points between pregnancy and 12 months of age. Non-linear mixed models were used to model maternal antibody decay in infants. The model-based median time to loss of antibodies was 3.6 months. The median child-specific time to loss of antibodies in children of naturally immune women (3.8 months) and children of vaccinated women (2.4 months) differed significantly (p = 0.025). The log antibody level of the mother and the log birth weight were correlated with the duration of maternal antibodies in infants (p < 0.0001). Conclusion: Children of vaccinated women loose maternal mumps antibodies significantly earlier in life compared to children of naturally infected women. If early administration (< 12 months) of the combined measles, mumps, and rubella vaccine is needed, maternal mumps antibodies are not expected to interfere with infant humoral vaccine responses. |
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Language
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English
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Source (journal)
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European journal of pediatrics. - Berlin
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Publication
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Berlin
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2012
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ISSN
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0340-6199
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Volume/pages
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171
:8
(2012)
, p. 1167-1173
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ISI
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000306682100004
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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