| Title |
|
|
|
Maternal mumps antibodies in a cohort of children up to the age of 1 year
|
|
| Author |
|
|
|
|
|
| Abstract |
|
|
|
| The duration of the presence of maternal mumps antibodies in a prospective cohort study is presented. Immunoglobulin G against mumps was portioned with a commercial ELISA test (EuroimmunA (R) anti-mumps Virus AT ELISA, Germany) on samples from 213 mother-child pairs at seven time points between pregnancy and 12 months of age. Non-linear mixed models were used to model maternal antibody decay in infants. The model-based median time to loss of antibodies was 3.6 months. The median child-specific time to loss of antibodies in children of naturally immune women (3.8 months) and children of vaccinated women (2.4 months) differed significantly (p = 0.025). The log antibody level of the mother and the log birth weight were correlated with the duration of maternal antibodies in infants (p < 0.0001). Conclusion: Children of vaccinated women loose maternal mumps antibodies significantly earlier in life compared to children of naturally infected women. If early administration (< 12 months) of the combined measles, mumps, and rubella vaccine is needed, maternal mumps antibodies are not expected to interfere with infant humoral vaccine responses. | |
|
| Language |
|
|
|
English
|
|
| Source (journal) |
|
|
|
European journal of pediatrics. - Berlin |
|
| Publication |
|
|
|
Berlin : 2012
|
|
| ISSN |
|
|
|
0340-6199
|
|
| Volume/pages |
|
|
|
171:8(2012), p. 1167-1173
|
|
| ISI |
|
|
|
000306682100004
|
|
| Full text (Publisher's DOI) |
|
|
| |
|
| Full text (publisher's version - intranet only) |
|
|
| |
|