Title
Human plasmacytoid dendritic cells are equipped with antigen presenting- and tumoricidal-capacities Human plasmacytoid dendritic cells are equipped with antigen presenting- and tumoricidal-capacities
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Human medicine
Source (journal)
Blood / American Society of Hematology. - New York, N.Y.
Volume/pages
120(2012) :19 , p. 3936-3944
ISSN
0006-4971
ISI
000311629600015
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Human plasmacytoid dendritic cells (pDCs) represent a highly specialized naturally occuring dendritic cell subset and are the main producers of type I interferons (IFN) in response to viral infections. We show that human pDCs activated by the preventive vaccine FSME specifically upregulate CD56 on their surface, a marker which was thought to be specific for NK cells and associated with cytolytic effector functions. We observed that FSME-activated pDCs specifically lysed NK target cells and expressed cytotoxic molecules such as TRAIL and granzyme B. Elevated levels of these molecules coincided with the expression of CD56, indicative for skewing human pDCs towards an interferon producing killer DC subset. Detailed phenotypical and functional analysis revealed that pDCs attained a mature phenotype, secreted pro-inflammatory cytokines and had the capacity to present antigens and stimulate T cells. We here report on the generation of CD56+ human interferon producing killer plasmacytoid DCs with the capacity to present antigens. These findings aid in deciphering the role for pDCs in anti-tumor immunity and present a promising prospect of developing anti-tumor therapy using pDCs.
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