Publication
Title
Rapid isolation and identification of minor natural products by LCMS, LCSPENMR and ECD : isoflavanones, biflavanones and bisdihydrocoumarins from **Ormocarpum kirkii**
Author
Abstract
The combination of the hyphenated techniques LCMS and LCSPENMR constitutes a powerful platform for the rapid isolation and identification of minor components from natural sources. Electronic circular dichroism (ECD) is a useful tool to determine the absolute configuration of small quantities of chiral molecules. In order to search for minor constituents present in an Ormocarpum kirkii extract, these techniques were applied for the separation and structure elucidation of a series of isoflavanones, biflavanones and biscoumarins. After optimization of chromatographic conditions and subsequent isolation, MS and 1D and 2D NMR data were collected. Experimental and calculated ECD spectra were used in conjunction with NMR data to confirm the absolute configuration of these compounds. Eight compounds were identified for the first time and six have been previously reported. The present approach offers a strategy for accelerating research on natural products.
Language
English
Source (journal)
Phytochemistry: an international journal of plant biochemistry. - Oxford
Publication
Oxford : 2012
ISSN
0031-9422
Volume/pages
79(2012), p. 121-128
ISI
000307031800012
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 28.09.2012
Last edited 06.08.2017
To cite this reference