Publication
Title
Designs for two-stage intensive screening of pharmaceutical production processes
Author
Abstract
Optimization of a pharmaceutical production process requires intensive screening to determine which factors from a predetermined list affect the properties of the product. The screening is called intensive because two-factor interactions (2fi) are likely to occur. Therefore, identification of main effects in an intensive screening situation requires a statistical design that permits estimation of these effects independent from estimation of 2fi. A recently completed catalog offers many two-level designs with 32, 40, and 48 runs that are suitable for this purpose. However, there may be practical reasons to divide the runs of a design into two equally sized blocks. In this article, I consider optimum blocking for the two-level designs in the catalog. This article has supplementary materials online.
Language
English
Source (journal)
Statistics in biopharmaceutical research
Publication
2012
Volume/pages
4:4(2012), p. 336-347
ISI
000309751000003
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.10.2012
Last edited 29.05.2017
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