Title
Basophil activation in the diagnosis of life-threatening hypersensitivity reaction to iodinated contrast media : a case report Basophil activation in the diagnosis of life-threatening hypersensitivity reaction to iodinated contrast media : a case report
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Leuven ,
Subject
Human medicine
Source (journal)
Acta clinica Belgica. - Leuven, 1946 - 1997
Volume/pages
68(2013) :2 , p. 140-142
ISSN
0001-5512
ISI
000319546900016
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Hypersensitivity to iodinated radiologic contrast media occurs in 1-3% of patients. A complete allergological work-up requires the identification of the pathogenetic mechanism as well as the identification of safe alternatives. The current diagnostic approach relies upon skin tests, since no other in vitro test is standardized. However skin tests do not have an absolute predictive value, cannot be executed immediately and may expose the patients to the risk of severe reactions. Recently the flow-cytometric evaluation of activated basophils, also known as basophil activation test (BAT) has been introduced. Our case report of a 28-year old female who experienced an anaphylactic shock immediately after administration of iomeprol supports the role of BAT in the diagnosis and management of hypersensitivity reactions to contrast media. The possibility of shortening the diagnostic work-up without endangering the health of patients represents the main advantage of this test.
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