Title
Layered double hydroxides reconstructed in calcium glutamate aqueous solution as a complex delivery system Layered double hydroxides reconstructed in calcium glutamate aqueous solution as a complex delivery system
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Amsterdam ,
Subject
Physics
Chemistry
Biology
Source (journal)
Applied clay science. - Amsterdam
Volume/pages
65/66(2012) , p. 37-42
ISSN
0169-1317
ISI
000309570800007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Hybrid structures of layered double hydroxides able to incorporate, store and controlled release both Ca(II) and glutamate were fabricated by using the ability of the hydrotalcite-like anionic clay to manifest its structural memory in the aqueous solution of calcium glutamate. X-ray diffraction, IR spectroscopy, X-Ray photoelectron spectroscopy, energy dispersive X-ray spectroscopy, transmission electron microscopy and thermal analyses evidence the formation of a hybrid system consisting of nanosized clusters of Ca(II) deposited on glutamate intercalated anionic clay. The resultant hybrid released Ca(II) rapidly with almost 80% release within 2 h though a profile of a much slower and sustained release, with ~ 54% release within 20 h is obtained for glutamate. The kinetic models fitted to the experimental data reveal that the mechanism of Ca(II) release is probably due to the surface and/or intraparticle diffusion while glutamate release is better fitted to the bulk diffusion via ionic exchange. The present findings demonstrate the tremendous promise of layered double hydroxides to develop complex therapeutics by incorporation and controlled delivery of multiply biologically active agents.
E-info
https://repository.uantwerpen.be/docman/iruaauth/cb3ed4/56eecd9b7c4.pdf
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