Title
Lymphangiogenesis may play a role in cultivated limbal stem cell transplant rejection Lymphangiogenesis may play a role in cultivated limbal stem cell transplant rejection
Author
Faculty/Department
Faculty of Medicine and Health Sciences
University Hospital Antwerp
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
Ocular immunology and inflammation / Cambridge Antiquarian Society. - London
Volume/pages
20(2012) :5 , p. 381-383
ISSN
0927-3948
ISI
000309471900013
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
We describe the clinicopathologic findings in a case of acute rejection following cultivated limbal stem cell transplantation (CLSC). This is the first time lymphangiogenesis has been described in CLSC rejection. This indicates that 1. absence of corneal stromal cells or 2. down regulation of HLA antigens by exposure to culture conditions, does not reduce the risk of graft rejection when transplanting into a high risk corneal bed. Our findings highlight the need for development of anti-lymphangiogenic treatments prior to CLSC transplantation.
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