| Title |
|
|
|
Assessment of gene-by-sex interaction effect on bone mineral density
|
|
| Author |
|
|
|
|
|
| Abstract |
|
|
|
| Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed expression quantitative trait loci (eQTL) analysis and bioinformatics network analysis. We conducted an autosomal genome-wide meta-analysis of gene-by-sex interaction on lumbar spine (LS) and femoral neck (FN) BMD in 25,353 individuals from 8 cohorts. In a second stage, we followed up the 12 top single-nucleotide polymorphisms (SNPs; p? | |
|
| Language |
|
|
|
English
|
|
| Source (journal) |
|
|
|
Journal of bone and mineral research. - New York, N.Y. |
|
| Publication |
|
|
|
New York, N.Y. : 2012
|
|
| ISSN |
|
|
|
0884-0431
|
|
| Volume/pages |
|
|
|
27:10(2012), p. 2051-2064
|
|
| ISI |
|
|
|
000308925800003
|
|
| Full text (Publisher's DOI) |
|
|
| |
|
| Full text (publisher's version - intranet only) |
|
|
| |
|