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Title
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Assessment of gene-by-sex interaction effect on bone mineral density
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Author
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Abstract
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| Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed expression quantitative trait loci (eQTL) analysis and bioinformatics network analysis. We conducted an autosomal genome-wide meta-analysis of gene-by-sex interaction on lumbar spine (LS) and femoral neck (FN) BMD in 25,353 individuals from 8 cohorts. In a second stage, we followed up the 12 top single-nucleotide polymorphisms (SNPs; p? |
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Language
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English
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Source (journal)
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Journal of bone and mineral research. - New York, N.Y.
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Publication
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New York, N.Y.
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2012
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ISSN
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0884-0431
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DOI
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10.1002/JBMR.1679
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Volume/pages
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27
:10
(2012)
, p. 2051-2064
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ISI
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000308925800003
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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