Publication
Title
Estimating the population prevalence and force of infection directly from antibody titres
Author
Abstract
The use of threshold values in order to diagnose individual subjects as being 'susceptible' or 'infected or recovered/immune' for a specific infection is virtually always prone to false positive, false negative or inconclusive classifications. Such misclassifications might lead to biased estimates for epidemiological parameters, such as the prevalence and the force of infection. In this article, we propose to estimate these epidemiological parameters directly from antibody titres, using an underlying mixture model. The method is applied to estimate the Salmonella serological prevalence in pigs and the age-dependent force of infection using serological data on the Varicella-Zoster virus (VZV) in humans. The threshold and direct method are compared through a simulation study.
Language
English
Source (journal)
Statistical modelling: an international journal. - Place of publication unknown
Publication
Place of publication unknown : 2012
ISSN
1471-082X
Volume/pages
12:5(2012), p. 441-462
ISI
000308652200003
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 22.11.2012
Last edited 19.09.2017
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