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Title
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Advances in hepatitis immunization (A, B, E) : public health policy and novel vaccine delivery
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Author
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Abstract
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| Purpose of review This review offers an update on hepatitis A, B and E vaccines based on relevant literature published in 2011-2012. Hepatitis A and B vaccines have been commercially available for years; however, the development of the hepatitis E vaccine is still facing some challenges. Recent findings Current scientific evidence shows that both hepatitis A and B vaccines confer long-term protection. These data supported the updated recommendations from the WHO on hepatitis A and B vaccines and the respective booster policy. In addition, a single-dose hepatitis A vaccination programme may be an option for some intermediate endemic countries, as far as the epidemiological situation is further monitored. Recent data illustrate the co-administration of hepatitis A with infant vaccines, as well as the interchangeability with other hepatitis A vaccines. Two genetically engineered hepatitis E vaccines are currently in development, showing more than 95% protective efficacy. Summary Follow-up of vaccinated individuals confirms the long-term protection offered by the hepatitis A as well as hepatitis B vaccines. Data confirm the safety and immunogenicity profile of both vaccines, also when used in patient groups. The first data on the hepatitis E vaccine look promising, but questions on cross-protection, long-term efficacy and safety and immunogenicity in pregnant women and children less than 2 years remain unanswered. |
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Language
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English
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Source (journal)
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Current opinion in infectious diseases. - London
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Publication
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London
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2012
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ISSN
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0951-7375
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DOI
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10.1097/QCO.0B013E328357E65C
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Volume/pages
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25
:5
(2012)
, p. 578-583
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ISI
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000308470400014
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Full text (Publisher's DOI)
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