Publication
Title
Altered circadian profiles in attention-deficit/hyperactivity disorder : an integrative review and theoretical framework for future studies
Author
Abstract
Disruptions in the sleep-wake cycle and the circadian system have been found in a wide range of psychiatric disorders and are generally correlated with clinical severity and diminished quality of life. Emerging evidence suggests similar disturbances may be found in attention-deficit/hyperactivity disorder (ADHD). Here we review the available literature on across the day fluctuations in ADHD-related processes in terms of; (i) time of day effects on behavior and activity; (ii) morningness-eveningness chronotypology; (iii) sleep/wake rhythms; and (iv) rhythmicity in neuroendocrine and neurophysiological responsiveness. On this basis, we propose a neurobiological framework to guide future study, which sees circadian effects in ADHD, along with other aspects of ADHD arousal-related deficits (e.g., cognitive energetic deficits), as being the result of dysregulated locus coeruleus function. Based on this perspective specific recommendations for future research are presented. (C) 2012 Elsevier Ltd. All rights reserved.
Language
English
Source (journal)
Neuroscience and biobehavioral reviews. - Fayetteville, N. Y, 1978, currens
Publication
Fayetteville, N. Y : ANKHO International Inc, 2012
ISSN
0149-7634
Volume/pages
36:8(2012), p. 1897-1919
ISI
000309098500008
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 22.11.2012
Last edited 23.06.2017
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