|
Title
|
|
|
|
The genetics of dementia with Lewy bodies : what are we missing?
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| Dementia with Lewy bodies is a complex brain disorder and a key member of the Lewy body disease spectrum. Its genetic etiology is unclear, and information is scattered. However, the results of molecular genetic studies imply a genetic and mechanistic overlap with Alzheimer disease, Parkinson disease with dementia, and Parkinson disease. In this review, we provide a comprehensive overview of the current studies on dementia with Lewy bodies heritability, genetic etiology, and genetic heterogeneity. We conclude with a critical discussion of the missing heritability in dementia with Lewy bodies and encourage scientists to further explore the underlying mechanisms of this disease. Arch Neurol. 2012; 69(9): 1113-1118. Published online May 28, 2012. doi:10.1001/archneurol.2011.3678 |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Archives of neurology / American Medical Association. - Chicago, Ill., 1960 - 2012
|
|
|
Publication
|
|
|
|
Chicago, Ill.
:
2012
|
|
|
ISSN
|
|
|
|
0003-9942
[print]
1538-3687
[online]
|
|
|
DOI
|
|
|
|
10.1001/ARCHNEUROL.2011.3678
|
|
|
Volume/pages
|
|
|
|
69
:9
(2012)
, p. 1113-1118
|
|
|
ISI
|
|
|
|
000308560600002
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|