Title
The genetics of dementia with Lewy bodies : what are we missing? The genetics of dementia with Lewy bodies : what are we missing?
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Chicago, Ill. ,
Subject
Human medicine
Source (journal)
Archives of neurology / American Medical Association. - Chicago, Ill., 1960 - 2012
Volume/pages
69(2012) :9 , p. 1113-1118
ISSN
0003-9942
1538-3687
ISI
000308560600002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Dementia with Lewy bodies is a complex brain disorder and a key member of the Lewy body disease spectrum. Its genetic etiology is unclear, and information is scattered. However, the results of molecular genetic studies imply a genetic and mechanistic overlap with Alzheimer disease, Parkinson disease with dementia, and Parkinson disease. In this review, we provide a comprehensive overview of the current studies on dementia with Lewy bodies heritability, genetic etiology, and genetic heterogeneity. We conclude with a critical discussion of the missing heritability in dementia with Lewy bodies and encourage scientists to further explore the underlying mechanisms of this disease. Arch Neurol. 2012; 69(9): 1113-1118. Published online May 28, 2012. doi:10.1001/archneurol.2011.3678
E-info
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