Title
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The genetics of dementia with Lewy bodies : what are we missing?
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Author
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Abstract
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Dementia with Lewy bodies is a complex brain disorder and a key member of the Lewy body disease spectrum. Its genetic etiology is unclear, and information is scattered. However, the results of molecular genetic studies imply a genetic and mechanistic overlap with Alzheimer disease, Parkinson disease with dementia, and Parkinson disease. In this review, we provide a comprehensive overview of the current studies on dementia with Lewy bodies heritability, genetic etiology, and genetic heterogeneity. We conclude with a critical discussion of the missing heritability in dementia with Lewy bodies and encourage scientists to further explore the underlying mechanisms of this disease. Arch Neurol. 2012; 69(9): 1113-1118. Published online May 28, 2012. doi:10.1001/archneurol.2011.3678 |
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Language
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English
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Source (journal)
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Archives of neurology / American Medical Association. - Chicago, Ill., 1960 - 2012
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Publication
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Chicago, Ill.
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2012
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ISSN
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0003-9942
[print]
1538-3687
[online]
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DOI
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10.1001/ARCHNEUROL.2011.3678
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Volume/pages
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69
:9
(2012)
, p. 1113-1118
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ISI
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000308560600002
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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