Title
Assessment of antimicrobial and antiprotozoal activity of the olive oil macerate samples of **Hypericum perforatum** and their LC-DAD-MS analyses Assessment of antimicrobial and antiprotozoal activity of the olive oil macerate samples of **Hypericum perforatum** and their LC-DAD-MS analyses
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Chemistry
Pharmacology. Therapy
Human medicine
Source (journal)
Food chemistry. - Amsterdam
Volume/pages
138(2013) :2-3 , p. 870-875
ISSN
0308-8146
ISI
000316039500023
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Twenty-one samples of traditionally-prepared (home-made) and ready-made (commercial) St. Johns Wort olive oil macerates were profiled for their in vitro antimicrobial and antiprotozoal activity. Their cytotoxic potential was evaluated on MRC-5 fibroblasts. In the antiprotozoal assays, ten of the oils inhibited T. brucei rhodesiense (IC50 15.9 - 64.5 μg/mL), while only one oil exerted antimicrobial activity towards S. aureus (IC50= 88.7 μg/mL). LC-DAD-MS data revealed the presence of pseudohypericin (0.135-3.280 μg/g) and hypericin (0.277-6.634 μg/g) in all the oils, whereas chlorogenic acid (1.063 μg/g) was detected only in one oil sample. Hyperforin was detected in four (0.977-2.399 μg/g) and adhyperforin in six samples (0.005-3.165 μg/g). Hypericin and pseudohypericin were common in the active oils, whereas hyperforin, adhyperforin, and chlorogenic acid were absent in these samples. Our results indicated that if the correct plant material is used, the infused oils from H. perforatum may contain active components.
E-info
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