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Title
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Antiplasmodial and cytotoxic activities of **Striga asiatica** and **Sauropus spatulifolius** extracts, and their isolated constituents
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Author
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Abstract
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| A phytochemical investigation of Striga asiatica and the leaves of Sauropus spatulifolius revealed seventeen compounds, three of which were reported for the first time from nature, i.e. two alkaloids N-hydroxyethyl-2-acetylpyrrole, N-(3-carboxypropyl)-2-acetylpyrrole, and 2-(4-hydroxy-2,2,6-trimethylcyclohexyl)acetic acid, for which the name sauropic acid was adopted. Their structures were established spectroscopically and by single-crystal X-ray diffraction analysis. All extracts and isolates were evaluated for antiplasmodial activity against Plasmodium falciparum strain K1 and for cytotoxicity against MRC-5 cells. |
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Language
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English
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Source (journal)
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Phytochemistry letters
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Publication
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2013
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ISSN
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1874-3900
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DOI
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10.1016/J.PHYTOL.2012.10.018
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Volume/pages
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6
:1
(2013)
, p. 53-58
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ISI
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000314477900012
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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