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Title
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Population-based screening for colorectal cancer using an immunochemical faecal occult blood test : a comparison of two invitation strategies
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Author
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Abstract
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| Background: To date, there is no screening programme for colorectal cancer (CRC) in Flanders, Belgium. However, The European Code Against Cancer (2003) recommends a population-based approach for CRC screening. This study aimed to obtain information about potential participation rates for a population-based screening programme for CRC in Flanders, and to compare two invitation strategies. Methods: In 2009, a trial programme for CRC screening was set up in three Flemish areas for all average-risk people aged 50-74 years, using an immunochemical faecal occult blood test (iFOBT) with a cut-off value set at 75 ng/ml of haemoglobin. The faecal sampling set was sent at random by post (mail group) or provided by the general practitioner (GP group). Results: In total, 19,542 people were invited to participate. Of these, 8229 provided a faecal sample, resulting in an overall participation rate of 42.1%. Participation by mail and through the GP was 52.3% (95% CI, 51.3-53.2) and 27.7% (95% CI, 26.7-28.6), respectively. The difference of 24.6% was statistically significant (95% CI, 23.3-25.9, p < 0.001). Before the reminder letter was sent and the other invitation strategy was offered, the overall participation rate was 26.5% (n = 5176); 36.4% (95% CI, 35.5-37.4) for the mail group and 16.6% (95% CI, 15.8-17.3) for the GP group. The odds of participating in CRC screening was almost three times higher for people invited by mail as opposed to people invited through a GP (OR = 2.96, 95% CI, 2.78-3.14, p < 0.001). Women were more likely to participate in CRC screening than men (OR = 1.22, 95% CI, 1.15-1.30, p < 0.001). In addition, we found that inhabitants from residential (OR = 1.98, 95% CI, 1.85-2.11) and rural (OR = 2.90, 95% CI, 2.66-3.16) areas were more likely to participate than those in urban areas. Of the 8229 people who submitted a faecal sample, 435 (5.3%) had a positive iFOBT, and of those, CRC was diagnosed in 18 (5.7%) individuals. Compliance for follow-up colonoscopy was 72.9%, and did not differ between the mail (72.4%, 95% CI, 67.5-77.3) and GP groups (74.3, 95% CI, 66.2-82.5). Conclusion: Inviting people for CRC screening by means of a direct-mail invitation, and including a faecal sampling set (iFOBT), results in much higher participation rates than inviting people through the GP. (C) 2012 Elsevier Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Cancer epidemiology
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Publication
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2012
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ISSN
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1877-7821
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DOI
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10.1016/J.CANEP.2012.04.003
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Volume/pages
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36
:5
(2012)
, p. E317-E324
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ISI
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000309818500009
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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