Title
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Leioa ,
Subject
Biology
Source (journal)
International journal of developmental biology. - Leioa
Volume/pages
56(2012) :5 , p. 363-368
ISSN
0214-6282
ISI
000309794700007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Regulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are mediated by other secretory Rab GTPases, such as Rab27A or Rab3 family members. In adult tissues, Rab27B is expressed in a wide variety of differentiated secretory epithelial cells, including those lining the salivary gland, gastrointestinal, mammary and prostate tracts. The complex pattern of Rab27B expression indicates that dysregulation of Rab27B-mediated secretion may have profound implications for disease pathology.
E-info
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