Title
Hazelnut allergy : a multi-faced condition with demographic and geographic characteristicsHazelnut allergy : a multi-faced condition with demographic and geographic characteristics
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Translational Pathophysiological Research (TPR)
Laboratory Experimental Medicine and Pediatrics (LEMP)
Faculteit Geneeskunde
Publication type
article
Publication
Leuven,
Subject
Human medicine
Source (journal)
Acta clinica Belgica. - Leuven, 1946 - 1997
Volume/pages
(2012), 5 p.
ISSN
0001-5512
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Hazelnut (Corylus avellana) allergy varies from rather mild oral allergy symptoms to potentially life-threatening anaphylaxis and exhibits geographic and age-related variations. Severity of symptoms depends on the sensitisation profile of the patient and can partially be predicted using component-resolved diagnosis. In our region (young) children predominantly exhibit sensitisation to hazelnut storage proteins Cor a 9 and Cor a 11 that is unrelated to birch pollen allergy and is generally associated with a more severe clinical outcome on consumptionon raw and processed hazelnut. In contrast, adults predominantly present with an oral allergy syndrome due to an extensive cross-reactivity between the labile Cor a 1.04 and Bet v 1, the major allergen from birch (Betula verrucosa) pollen. In the absence of a cure, avoidance remains the key measure of effective management, particularly in those patients presenting with a severe form.
E-info
https://repository.uantwerpen.be/docman/iruaauth/0baea9/a2a4cc3530f.pdf
Handle