Publication
Title
Diarylquinolines, synthesis pathways and quantitative structure-activity relationship studies leading to the discovery of TMC207
Author
Abstract
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis and resistance to current anti-TB drugs call for the discovery and development of new effective anti-TB drugs. TMC207 is the lead candidate of a novel class of antimycobacterial agents, the diarylquinolines, which specifically inhibit mycobacterial ATP synthase and displays high activity against both drug-susceptible and multidrug-resistant strains of Mycobacterium tuberculosis. This article covers both synthesis pathways as well as qualitative and quantitative analyses of the structureactivity relationships of the diarylquinoline series on Mycobacterium smegmatis activity.
Language
English
Source (journal)
Future medicinal chemistry
Publication
2011
Volume/pages
3:11(2011), p. 1345-1360
ISI
000294544900009
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 02.01.2013
Last edited 12.04.2017
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