Title
Towards elimination: measles susceptibility in Australia and 17 European countries Towards elimination: measles susceptibility in Australia and 17 European countries
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Genève ,
Subject
Human medicine
Source (journal)
Bulletin of the World Health Organization. - Genève
Volume/pages
86(2008) :3 , p. 197-204
ISSN
0042-9686
ISI
000253850800010
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Objective To evaluate age-specific measles susceptibility in Australia and 17 European countries. Methods As part of the European Sero-Epidemiology Network 2 (ESEN2), 18 countries collected large national serum banks between 1996 and 2004. These banks were tested for measles IgG and the results converted to a common unitage to enable valid intercountry comparisons. Historical vaccination and disease incidence data were also collected. Age-stratified population susceptibility levels were compared to WHO European Region targets for measles elimination of < 15% in those aged 2-4 years, < 10% in 5-9-year-olds and < 5% in older age groups. Findings Seven countries (Czech Republic, Hungary, Luxembourg, Spain, Slovakia, Slovenia and Sweden) met or came very close to the elimination targets. Four countries (Australia, Israel, Lithuania and Malta) had susceptibility levels above WHO targets in some older age groups indicating possible gaps in protection. Seven countries (Belgium, Bulgaria, Cyprus, England and Wales, Ireland, Latvia and Romania) were deemed to be at risk of epidemics as a result of high susceptibility in children and also, in some cases, adults. Conclusion Although all countries now implement a two-dose measles vaccination schedule, if the WHO European Region target of measles elimination by 2010 is to be achieved higher routine coverage as well as vaccination campaigns in some older age cohorts are needed in some countries. Without these improvements, continued measles transmission and outbreaks are expected in Europe.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/d76eb5/4438.pdf
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