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Title
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Prospective evaluation of virulence factors of enterococci isolated from patients with peritonitis: impact on outcome
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Author
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Abstract
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| The objective of this study was to evaluate the prevalence of 4 virulence factors (VFs) of enterococci (cytolysin [cyl], gelatinase [gel], aggregation substance [agg], and enterococcal surface protein [esp]) and their relationship to outcome in patients with generalized peritonitis in a prospective cohort study. VF expression in each strain was assessed by polymerase chain reaction assay with specific primers. Outcome of the patients was recorded. Ninety-nine strains of Enterococcus were obtained from the peritoneal fluid of 81 patients. Fifty-eight patients had at least 1 strain bearing [cyl] (13.1% of the strains), [gel] (50.5% of the strains), [agg] (40.4% of the strains), and [esp] (34.3% of the strains). The presence of VF of Enterococcus was independently associated with mortality: odds ratio, 5.5; 95% confidence interval, 1.3-28.1. In conclusion, VF accounted for 72% of the patients with enterococci isolated from the peritoneal fluid and was independently associated with mortality in severe peritonitis. (c) 2008 Elsevier Inc. All rights reserved. |
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Language
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English
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Source (journal)
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Diagnostic microbiology and infectious disease. - Amsterdam
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Publication
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Amsterdam
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2008
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ISSN
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0732-8893
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DOI
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10.1016/J.DIAGMICROBIO.2007.10.006
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Volume/pages
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60
:3
(2008)
, p. 247-253
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ISI
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000253893500002
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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