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Title
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Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease
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Author
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Abstract
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| An in situ approach was used to identify the oxidized RNA nucleoside 8-hydroxyguanosine (8OHG) in the frontal cortex of familial Alzheimer's disease (FAD) with a mutation in presenilin-1 (PS-1) or amyloid protein precursor (AOPP) gene (n = 13, age 47-81 years). Neurons with marked 80HG immunoreaction in the cytoplasm were widely distributed in the superior/middle frontal gyros of FAD. Relative intensity measurements of neuronal 80HG immunoreactivity showed that there was a significant increase in FAD compared with controls (n = 15, age 59-81 years), while there was no difference in relative 80HG between the PS-1 and the AOPP FAD. Interestingly, a presymptomatic case carrying a PS-1 mutation showed a considerable level of relative 8OHG, and the increased levels of neuronal 80HG in FAD were more prominent in cases with a lower percentage area of Abeta42 burden. These results suggest that oxidative stress is an early event involved in the pathological cascade of FAD. (C) 2004 Elsevier Inc. All rights reserved. |
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Language
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English
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Source (journal)
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Neurobiology of disease. - San Diego, Calif.
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Publication
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San Diego, Calif.
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2004
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ISSN
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0969-9961
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DOI
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10.1016/J.NBD.2004.06.003
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Volume/pages
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17
:1
(2004)
, p. 108-113
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ISI
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000223944200012
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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