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Title
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Family-based association studies of -adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder
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Author
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Abstract
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| Several lines of evidence suggest an involvement of the noradrenergic neurotransmitter system in the pathogenesis of bipolar affective disorder (BPAD). Three genes for alpha-adrenergic receptors (ADRA) are located in chromosomal regions that showed evidence for linkage: The alpha(1c)-adrenergic (ADRA-1C) receptor gene on 8p21, the alpha(2a)-adrenergic (ADRA-2A) receptor gene on 10q25, and the alpha(2c)-adrenergic (ADRA-2C) receptor on 4p16. In a BPAD sample of 120 parent-offspring triads, we genotyped a 492 Cys/Arg variant in exon 2 of the ADRA-1C gene, a -1291 G/C variant in the 5' UTR of the ADRA-2A gene, and a STR marker (adra2c1) in the 5' UTR of the ADRA-2C gene. Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes. (C) 2003 Wiley-Liss, Inc. |
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Language
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English
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Source (journal)
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American journal of medical genetics. - New York, N.Y., 1977 - 2002
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Publication
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New York, N.Y.
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2004
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ISSN
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0148-7299
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DOI
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10.1002/AJMG.B.20145
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Volume/pages
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126B
:1
(2004)
, p. 79-81
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ISI
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000220607300015
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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