Title
Family-based association studies of <tex>$\alpha$</tex>-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder Family-based association studies of <tex>$\alpha$</tex>-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Human medicine
Source (journal)
American journal of medical genetics. - New York, N.Y., 1977 - 2002
Volume/pages
126B(2004) :1 , p. 79-81
ISSN
0148-7299
ISI
000220607300015
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Several lines of evidence suggest an involvement of the noradrenergic neurotransmitter system in the pathogenesis of bipolar affective disorder (BPAD). Three genes for alpha-adrenergic receptors (ADRA) are located in chromosomal regions that showed evidence for linkage: The alpha(1c)-adrenergic (ADRA-1C) receptor gene on 8p21, the alpha(2a)-adrenergic (ADRA-2A) receptor gene on 10q25, and the alpha(2c)-adrenergic (ADRA-2C) receptor on 4p16. In a BPAD sample of 120 parent-offspring triads, we genotyped a 492 Cys/Arg variant in exon 2 of the ADRA-1C gene, a -1291 G/C variant in the 5' UTR of the ADRA-2A gene, and a STR marker (adra2c1) in the 5' UTR of the ADRA-2C gene. Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes. (C) 2003 Wiley-Liss, Inc.
E-info
https://repository.uantwerpen.be/docman/iruaauth/b44acc/02d4600.pdf
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