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Small dense-cored vesicles are depleted of the classical synaptic vesicle membrane proteins synaptobrevin, synaptotagmin and Rab3
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| Abstract |
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| To verify the association of vesicular docking/fusion proteins to small dense-cored vesicles, we further purified a small dense-cored vesicle population from rat vas deferens and searched for three components of the vesicular docking/fusion machinery known to act on target receptors at the plasma membrane: synaptobrevin (p18), synaptotagmin (p65) and the small GTPase Rab3. Further purification of small dense-cored vesicles actually resulted in a depletion of these proteins, arguing against a direct participation of small dense-cored vesicles in the exocytotic process. This finding points to a functional difference between small dense-cored vesicles and either large dense-cored or small clear synaptic vesicles. |
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English
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Neuroscience research communications. - Chichester | |
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Chichester : 2001
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0893-6609
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28:3(2001), p. 173-179
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000169591300004
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