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Title
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Small dense-cored vesicles are depleted of the classical synaptic vesicle membrane proteins synaptobrevin, synaptotagmin and Rab3
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Author
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Abstract
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| To verify the association of vesicular docking/fusion proteins to small dense-cored vesicles, we further purified a small dense-cored vesicle population from rat vas deferens and searched for three components of the vesicular docking/fusion machinery known to act on target receptors at the plasma membrane: synaptobrevin (p18), synaptotagmin (p65) and the small GTPase Rab3. Further purification of small dense-cored vesicles actually resulted in a depletion of these proteins, arguing against a direct participation of small dense-cored vesicles in the exocytotic process. This finding points to a functional difference between small dense-cored vesicles and either large dense-cored or small clear synaptic vesicles. |
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Language
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English
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Source (journal)
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Neuroscience research communications. - Chichester
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Publication
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Chichester
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2001
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ISSN
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0893-6609
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DOI
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10.1002/NRC.1018
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Volume/pages
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28
:3
(2001)
, p. 173-179
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ISI
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000169591300004
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Full text (Publisher's DOI)
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