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Title
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Interleukin-1 β : a putative mediator of hpa axis hyperactivity in major depression
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Author
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Abstract
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| Objective: There is extensive evidence that major depression, and particularly melancholia, is characterized by hypothalamic-pituitary-adrenal (HPA) axis hyperactivity as well as systemic immune activation, which may be accompanied by increased interleukin-1beta production. Interleukin-1beta is known to enhance HPA axis activity during an immune response. This study investigated whether interleukin-1beta production is related to HPA axis activity in depressed subjects. Method: The subjects were 28 inpatients with major or minor depression and 10 normal comparison subjects. The authors measured 1) the subjects' cortisol levels after an overnight 1-mg dexamethasone suppression test (DST) and 2) mitogen-stimulated supernatant interleukin-1beta production by peripheral blood mononuclear cells. Results: Statistically significant positive correlations between interleukin-1beta production and post-DST cortisol values were found in the study group as a whole and in the depressed and normal subgroups separately. Conclusions: It is suggested that constituents of the immune response (such as interleukin-1beta) in major depression may contribute to HPA axis hyperfunction in that illness. |
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Language
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English
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Source (journal)
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The American journal of psychiatry. - Washington, D.C.
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Publication
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Washington, D.C.
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1993
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ISSN
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0002-953X
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Volume/pages
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150
:8
(1993)
, p. 1189-1193
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ISI
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A1993LP80600009
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