Title
Interleukin-1 β : a putative mediator of hpa axis hyperactivity in major depression Interleukin-1 β : a putative mediator of hpa axis hyperactivity in major depression
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Washington, D.C. ,
Subject
Human medicine
Source (journal)
The American journal of psychiatry. - Washington, D.C.
Volume/pages
150(1993) :8 , p. 1189-1193
ISSN
0002-953X
ISI
A1993LP80600009
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Objective: There is extensive evidence that major depression, and particularly melancholia, is characterized by hypothalamic-pituitary-adrenal (HPA) axis hyperactivity as well as systemic immune activation, which may be accompanied by increased interleukin-1beta production. Interleukin-1beta is known to enhance HPA axis activity during an immune response. This study investigated whether interleukin-1beta production is related to HPA axis activity in depressed subjects. Method: The subjects were 28 inpatients with major or minor depression and 10 normal comparison subjects. The authors measured 1) the subjects' cortisol levels after an overnight 1-mg dexamethasone suppression test (DST) and 2) mitogen-stimulated supernatant interleukin-1beta production by peripheral blood mononuclear cells. Results: Statistically significant positive correlations between interleukin-1beta production and post-DST cortisol values were found in the study group as a whole and in the depressed and normal subgroups separately. Conclusions: It is suggested that constituents of the immune response (such as interleukin-1beta) in major depression may contribute to HPA axis hyperfunction in that illness.
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