Title
Regional cerebral blood flow in unipolar depression measured with Tc-99m-HMPAO single photon emission computed tomography : negative findings Regional cerebral blood flow in unipolar depression measured with Tc-99m-HMPAO single photon emission computed tomography : negative findings
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Psychiatry research. - Amsterdam
Psychiatry research: neuroimaging / International Society for Neuroimaging in Psychiatry. - Limerick
Volume/pages
50(1993) :2 , p. 77-88
ISSN
0165-1781
ISI
A1993LK62400002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Recent studies have reported that patients with unipolar major depression may show a lower whole brain cerebral blood flow (CBF) and reduced regional CBF in frontal, temporal, and parietal lobes. The present study used single photon emission computed tomography (SPECT) with the CBF marker Tc-99m-hexamethylpropyleneamineoxine (HMPAO) to measure the cortical CBF of six individual regions of interest (ROIs), total ROI, and left or right hemispheric total ROI in 43 unipolar depressed subjects and 12 normal control subjects. There were no significant differences in the distribution of Tc-99m-HMPAO uptake into total ROI, right or left global ROI, prefrontal, motor frontal, parietal, temporal, visual cortex, or associative visual cortex between patients with melancholic depression, simple major depression, or minor depression and healthy control subjects. There were also no significant differences in the right-left distribution of uptake between the patients and the control subjects. Hypoperfusion was observed in motor frontal and parietal cortex of patients who had been taking benzodiazepines during the study period. It is concluded that cortical CBF, as assessed with Tc-99m-HMPAO SPECT, is relatively intact in the present sample of patients with severe depression.
E-info
https://repository.uantwerpen.be/docman/iruaauth/8773ba/3bf4880.pdf
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