Title
Muramyldipeptide and granulocyte-macrophage colony-stimulating factor enhance interferon-<tex>$\gamma$</tex>-induced nitric-oxide production by rat alveolar macrophages
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Basel ,
Subject
Chemistry
Pharmacology. Therapy
Source (journal)
Agents and actions. - Basel
Volume/pages
38(1993) :1-2 , p. 100-105
ISSN
0065-4299
ISI
A1993KU84200016
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines. The enhancement was dependent on the presence of L-arginine in the incubation medium. It was based on a simple synergism between interferon-gamma and muramyldipeptide and a priming effect of granulocyte-macrophage colony-stimulating factor for interferon-gamma-induced nitrite production. These data suggest that cytokine networks are important in the induction of nitric oxide in rat alveolar macrophages.
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