Publication
Title
Muramyldipeptide and granulocyte-macrophage colony-stimulating factor enhance interferon--induced nitric-oxide production by rat alveolar macrophages
Author
Abstract
Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines. The enhancement was dependent on the presence of L-arginine in the incubation medium. It was based on a simple synergism between interferon-gamma and muramyldipeptide and a priming effect of granulocyte-macrophage colony-stimulating factor for interferon-gamma-induced nitrite production. These data suggest that cytokine networks are important in the induction of nitric oxide in rat alveolar macrophages.
Language
English
Source (journal)
Agents and actions. - Basel
Publication
Basel : 1993
ISSN
0065-4299
Volume/pages
38:1-2(1993), p. 100-105
ISI
A1993KU84200016
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 22.09.2017
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