Title
Muramyldipeptide and granulocyte-macrophage colony-stimulating factor enhance interferon-<tex>$\gamma$</tex>-induced nitric-oxide production by rat alveolar macrophagesMuramyldipeptide and granulocyte-macrophage colony-stimulating factor enhance interferon-<tex>$\gamma$</tex>-induced nitric-oxide production by rat alveolar macrophages
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Research group
Laboratory Experimental Medicine and Pediatrics (LEMP)
Faculteit Geneeskunde
Translational Pathophysiological Research (TPR)
Physiopharmacology (PHAR)
Publication type
article
Publication
Basel,
Subject
Chemistry
Pharmacology. Therapy
Source (journal)
Agents and actions. - Basel
Volume/pages
38(1993):1-2, p. 100-105
ISSN
0065-4299
ISI
A1993KU84200016
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines. The enhancement was dependent on the presence of L-arginine in the incubation medium. It was based on a simple synergism between interferon-gamma and muramyldipeptide and a priming effect of granulocyte-macrophage colony-stimulating factor for interferon-gamma-induced nitrite production. These data suggest that cytokine networks are important in the induction of nitric oxide in rat alveolar macrophages.
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