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Title
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Muramyldipeptide and granulocyte-macrophage colony-stimulating factor enhance interferon--induced nitric-oxide production by rat alveolar macrophages
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Author
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Abstract
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| Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines. The enhancement was dependent on the presence of L-arginine in the incubation medium. It was based on a simple synergism between interferon-gamma and muramyldipeptide and a priming effect of granulocyte-macrophage colony-stimulating factor for interferon-gamma-induced nitrite production. These data suggest that cytokine networks are important in the induction of nitric oxide in rat alveolar macrophages. |
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Language
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English
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Source (journal)
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Agents and actions. - Basel
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Publication
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Basel
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1993
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ISSN
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0065-4299
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DOI
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10.1007/BF02027220
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Volume/pages
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38
:1-2
(1993)
, p. 100-105
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ISI
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A1993KU84200016
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Full text (Publisher's DOI)
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