Title
Spinal sufentanil in rats : III. Effect of diluent volume on epidural sufentanil Spinal sufentanil in rats : III. Effect of diluent volume on epidural sufentanil
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Copenhagen ,
Subject
Human medicine
Source (journal)
Acta anaesthesiologica scandinavica. - Copenhagen
Volume/pages
36(1992) :4 , p. 305-308
ISSN
0001-5172
ISI
A1992HR87000003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Male Wistar rats were injected epidurally with various doses of sufentanil in 3 different dilution volumes, in order to determine differences in the lowest ED50 values for analgesia and side-effects. The lowest ED50 for both a TWR latency > 6 and greater-than-or-equal-to 10 s was significantly lower in the 20-mu-l group as compared to the 2-mu-l group. With an injection of 5-mu-l, intermediate values were obtained. With regard to the side-effects, there was a trend towards increased systemic resorption with larger diluent volumes in spite of a better and more selective spinal effect, as evidenced by increasing specificity ratios. In terms of duration of analgesia at fixed doses of sufentanil, different results were obtained. At low doses of sufentanil, a pronounced diluent volume effect was present and the duration of analgesia increased as a function of the volume. At higher doses of sufentanil, however, the volume effect faded away and no differences were observed as a function of the diluent.
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