Title
Higher <tex>$\alpha_{1}$</tex>-antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding-protein plasma levels during depression : further evidence for the existence of an inflammatory response during that illness Higher <tex>$\alpha_{1}$</tex>-antitrypsin, haptoglobin, ceruloplasmin and lower retinol binding-protein plasma levels during depression : further evidence for the existence of an inflammatory response during that illness
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Journal of affective disorders. - Amsterdam
Volume/pages
24(1992) :3 , p. 183-192
ISSN
0165-0327
ISI
A1992HM93500007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Recently, a few reports have shown that severe depression may be associated with higher levels of positive acute phase proteins (APPs), such as haptoglobin (Hp), alpha-1-acid glycoprotein (alpha-1S) and lower levels of negative APPs (visceral proteins), such as albumin (Alb) and transferrin (Tf). In order to reassess whether depression is related to alterations in the expression of plasma APP concentrations, we measured in 84 normal controls and depressed inpatients positive APPs such as Hp, alpha-1-antitrypsin (alpha-1AT), hemopexin (Hpx), ceruloplasmin (Cp), complement component C3C and one visceral protein, i.e., retinol binding protein (RBP). We found increased plasma concentrations of Hp, alpha-1AT, and Cp in major depressed subjects as compared with healthy controls, with minor depressives exhibiting an intermediate position. RBP was significantly lower in minor and major depressives than in normal controls. The disorders in these proteins were rather sensitive (62%) for major depression, with a specificity equalling 96%. Our findings are compatible with the hypothesis that major depression may be accompanied by inflammatory changes with higher levels of positive APPs (i.e., alpha-1AT, Hp, Cp, alpha-1S) and lower levels of visceral proteins (i.e., RBP, Tf, Alb).
E-info
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