Title
Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
European heart journal. - London
Volume/pages
26(2005) :19 , p. 1945-1955
ISSN
0195-668X
1522-9645
ISI
000232103200006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Well-known risk factors for atherosclerosis include hypercholesterolaemia, hypertension, diabetes, and smoking. These conditions are associated with endothelial dysfunction, which itself is associated with reduced endothelial generation of nitric oxide (NO). This is an overview of the implications of NO generation in atherosclerosis and of the potential therapeutic benefit of drugs which donate NO, such as organic nitrates, nicorandil, and sydnonimines, or those which increase the availability of endogenous NO, such as statins, angiotensin-converting enzyme inhibitors, L-arginine, and tetrahydrobiopterin.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/efb192/5780.pdf
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