Title
T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients
Author
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Psychiatry research. - Amsterdam
Volume/pages
129(2004) :3 , p. 267-272
ISSN
0165-1781
ISI
000226993400006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
It has been reported that the balance between T-helper type I (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-beta1), has been shown to modulate the production of Th1 and Th2 cytokines. However, the role of TGF-beta1 in bipolar disorder has not yet been explored. A total of 70 manic patients with bipolar disorder and 96 normal controls was recruited. The plasma levels of IFN-gamma, IL-4, and TGF-beta1 were studied at the time of admission and 8 weeks after mood stabilizer treatment. The detection rate and plasma concentrations of IFN-gamma and IL-4 and the IFN-gamma/TGF-beta1 and IL-4/TGF+beta1 ratios were significantly higher in patients than in controls, while the TGF-beta1 level was significantly lower. The TGF-beta1 level increased significantly after treatment and the IFN-gamma/TGF-beta1 and IL-4/TGF-beta1 ratios returned to control values. TGF-beta1 may play a role in the pathophysiology of bipolar disorder through the action of TGF-beta1 in modulating the IL-4/TGF-beta1 ratio. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
E-info
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