|
Title
|
|
|
|
T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| It has been reported that the balance between T-helper type I (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-beta1), has been shown to modulate the production of Th1 and Th2 cytokines. However, the role of TGF-beta1 in bipolar disorder has not yet been explored. A total of 70 manic patients with bipolar disorder and 96 normal controls was recruited. The plasma levels of IFN-gamma, IL-4, and TGF-beta1 were studied at the time of admission and 8 weeks after mood stabilizer treatment. The detection rate and plasma concentrations of IFN-gamma and IL-4 and the IFN-gamma/TGF-beta1 and IL-4/TGF+beta1 ratios were significantly higher in patients than in controls, while the TGF-beta1 level was significantly lower. The TGF-beta1 level increased significantly after treatment and the IFN-gamma/TGF-beta1 and IL-4/TGF-beta1 ratios returned to control values. TGF-beta1 may play a role in the pathophysiology of bipolar disorder through the action of TGF-beta1 in modulating the IL-4/TGF-beta1 ratio. (C) 2004 Elsevier Ireland Ltd. All rights reserved. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Psychiatry research. - Amsterdam
|
|
|
Publication
|
|
|
|
Amsterdam
:
2004
|
|
|
ISSN
|
|
|
|
0165-1781
|
|
|
DOI
|
|
|
|
10.1016/J.PSYCHRES.2004.08.005
|
|
|
Volume/pages
|
|
|
|
129
:3
(2004)
, p. 267-272
|
|
|
ISI
|
|
|
|
000226993400006
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|