Title
Rapid improvement of bone metabolism after infliximab treatment in Crohn's disease Rapid improvement of bone metabolism after infliximab treatment in Crohn's disease
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oxford ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
Alimentary pharmacology and therapeutics. - Oxford
Volume/pages
20(2004) :6 , p. 607-614
ISSN
0269-2813
ISI
000223713300003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: Crohn's disease is associated with low bone mineral density and altered bone metabolism. Aim: To assess the evolution of bone metabolism in Crohn's disease patients treated with infliximab. Methods: We studied 71 Crohn's disease patients treated for the first time with infliximab for refractory Crohn's disease. Biochemical markers of bone formation (type-I procollagen N-terminal propeptide, bone-specific alkaline phosphatase, osteocalcin) and of bone resorption (C-telopeptide of type-I collagen) were measured in the serum before and 8 weeks after infliximab therapy and compared with values in a matched healthy control group. Results: Eight weeks after treatment with infliximab, a normalization of bone markers was observed with a median increase in formation markers of 14-51% according to marker and a lower but significant decrease in resorption marker (median 11%). A clinically relevant increase in bone formation markers was present in 30-61% of patients according to the marker. A clinically relevant decrease in C-telopeptide of type-I collagen was present in 38% of patients. No association was found with any tested demographic or clinical parameter. Conclusion: Infliximab therapy in Crohn's disease may rapidly influence bone metabolism by acting either on bone formation or bone resorption. This improvement seems to be independent of clinical response to infliximab.
E-info
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https://repository.uantwerpen.be/docman/iruaauth/07dc96/71110341.pdf
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