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Title
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Rapid improvement of bone metabolism after infliximab treatment in Crohn's disease
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Author
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Abstract
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| Background: Crohn's disease is associated with low bone mineral density and altered bone metabolism. Aim: To assess the evolution of bone metabolism in Crohn's disease patients treated with infliximab. Methods: We studied 71 Crohn's disease patients treated for the first time with infliximab for refractory Crohn's disease. Biochemical markers of bone formation (type-I procollagen N-terminal propeptide, bone-specific alkaline phosphatase, osteocalcin) and of bone resorption (C-telopeptide of type-I collagen) were measured in the serum before and 8 weeks after infliximab therapy and compared with values in a matched healthy control group. Results: Eight weeks after treatment with infliximab, a normalization of bone markers was observed with a median increase in formation markers of 14-51% according to marker and a lower but significant decrease in resorption marker (median 11%). A clinically relevant increase in bone formation markers was present in 30-61% of patients according to the marker. A clinically relevant decrease in C-telopeptide of type-I collagen was present in 38% of patients. No association was found with any tested demographic or clinical parameter. Conclusion: Infliximab therapy in Crohn's disease may rapidly influence bone metabolism by acting either on bone formation or bone resorption. This improvement seems to be independent of clinical response to infliximab. |
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Language
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English
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Source (journal)
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Alimentary pharmacology and therapeutics. - Oxford
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Publication
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Oxford
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2004
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ISSN
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0269-2813
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DOI
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10.1111/J.1365-2036.2004.02152.X
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Volume/pages
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20
:6
(2004)
, p. 607-614
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ISI
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000223713300003
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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