Publication
Title
Multifunctional role of matrix metalloproteinases in multiple myeloma : a study in the 5T2MM mouse model
Author
Abstract
matrix metalloproteinases (mmPs) are known to play a role in cell growth, invasion, angiogenesis, metastasis, and bone degradation, all important events in the pathogenesis of cancer. Multiple myeloma is a B-cell cancer characterized by the proliferation of malignant plasma cells in the bone marrow, increased angiogenesis, and the development of osteolytic bone disease. The role of MMPs in the development of multiple mycloma is poorly understood. using sc-964, a potent 'inhibitor of several MMPS (MMP-2, -3, -8, -9, and -13), we investigated the role of MMPs in the 5T2MM Murine modeL Reverse transcriptase-polymerase chain reaction demonstrated the presence of mRNA for MMP-2, -8, -9, and -13 in 5T2MM-diseased bone marrow. Mice bearing 5T2MM cells were given access to food containing SC-964. The concentration of SC-964 measured in the plasma of mice after 11 days of treatment was able to inhibit MMP-9 activity in gelatin zymography. Treatment of 5T2MM-bearing mice resulted in a significant reduction in tumor burden, a significant decrease in angiogenesis, and partially protective effect against the development of osteolytic bone disease. The direct role of MMPs in these different processes was confirmed by in vitro experiments. All these results support the multMinctional role of mmPs in the development of multiplemyeloma.
Language
English
Source (journal)
The American journal of pathology. - Bethesda, Md
Publication
Bethesda, Md : 2004
ISSN
0002-9440
Volume/pages
165:3(2004), p. 869-878
ISI
000223732000016
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 22.04.2017