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Title
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Efficacy and tolerability of lanreotide autogel therapy in acromegalic patients previously treated with octreotide LAR
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Author
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Abstract
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| Objective: This open label, multicentre study was designed to evaluate the efficacy and tolerability of lanreotide Autogel (L-Autogel) in acromegalic patients over a 24-week period. The outcome of treatment with this new, long-acting, aqueous formulation of lanreotide was also compared with the patients' previous treatment with octreotide long acting repeatable (LAR). Design and methods: Twenty-five acromegalic patients (13 males, mean age 51+/-12 years) were switched from octreotide LAR (20-40 mg/4 weeks for at least 6 months) to L-Autogel, given deep subcutaneously at a fixed dose of 90 mg/4 weeks. After 12 weeks, the dose of L-Autogel was titrated according to patients' mean GH and IGF-I levels at week 8. It was increased to 120 mg/4 weeks if GH > 2.5 mug/l or if IGF-I was above the age-adjusted normal range. It was reduced to 60 mg/4 weeks if mean GH < 1 mug/l and IGF-I was within the normal range. If the values did not fall within these ranges, the dose remained unchanged at 90 mg. Results: After 24 weeks of treatment with L-Autogel (final doses 60 mg in 3 patients, 90 mg in 4 patients and 120 mg in 18 patients), mean serum GH (2.9+/-2.4 mug/l) and IGF-I concentrations (332+/-193 mug/l) remained statistically unchanged when compared with baseline values under octreotide LAR (GH 2.4+/-1.8 mug/l and IGF-I 337+/-201 mug/l, non significant (NS)). There was a significant improvement of the acromegalic symptom score over the study period, from 4.8+/-3.4 to 2.8+/-2.5 (P < 0.001) and a small but significant reduction in the residual pituitary tumour volume (P < 0.05). Local side-effects were observed less frequently and no technical problems were encountered with the L-Autogel injections, as opposed to treatment with octreotide LAR (60 difficult injections/150 (P < 0.001)). Conclusions: L-Autogel appears to be as effective as octreotide LAR in lowering GH and IGF-I concentrations in acromegalic patients. This treatment was also well tolerated by the patients, giving fewer local side-effects and technical problems with injections. These advantages may improve the long-term acceptability of medical treatment in acromegaly. |
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Language
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English
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Source (journal)
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European journal of endocrinology / European Society of Endocrinology [Bristol] - Copenhagen, 1994, currens
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Publication
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Copenhagen
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2004
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ISSN
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0804-4643
[print]
1479-683X
[online]
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DOI
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10.1530/EJE.0.1510317
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Volume/pages
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151
:3
(2004)
, p. 317-324
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ISI
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000224055800004
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Full text (Publisher's DOI)
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Full text (open access)
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