Title
Pathology of malignant mesothelioma Pathology of malignant mesothelioma
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Lung cancer: journal of the International Association for the Study of Lung Cancer / International Association for the Study of Lung Cancer [Aurora, Colo.] - Amsterdam
Source (book)
2nd Heidelberg Thoracic Oncology Symposium on the Diagnosis and, Treatment of Pleural Mesothelioma, MAY 10-11, 2002, Heidelberg, GERMANY
Volume/pages
45(2004) :s:[1] , p. S35-S36
ISSN
0169-5002
ISI
000223057700008
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The diagnosis of malignant mesothelioma relies firstly on the identification of the mesothelial nature of the neoplastic cell and secondly on the demonstration of the invasive properties of the proliferation. The latter aspect cannot be achieved by studying cellular material yet, in the right clinical setting, it is often possible to make a presumptive diagnosis of malignant mesothelioma based on exudates. Differentiation between mesothelial hyperplasia and metastatic adenocarcinoma by cytological examination atone is unreliable, so further evidence can be gathered from techniques such as histopathology, histochemistry and electron microscopy. Immunohistochemistry aims to confirm the mesothelial nature of the neoplastic cells while ruling out metastatic lesions. At present there is no single reliable marker for neoplastic mesothelioma, although evidence has been presented on a large variety of gene products. In an attempt to differentiate between hyperplastic mesothelium and malignant mesothelioma, Dhaene has been able to show that over 90% of malignant mesotheliomas show telomerase activity and express telomerase subunits. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
E-info
https://repository.uantwerpen.be/docman/iruaauth/e73676/3025829.pdf
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000223057700008&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000223057700008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000223057700008&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848