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Title
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Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women
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Author
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Abstract
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| Panic disorder is an anxiety disorder with an estimated heritability of up to 48%. Pharmacological and genetic studies suggest that genes coding for proteins involved in the catecholaminergic system might be relevant for the pathogenesis of the disease. In the present study, we genotyped a single nucleotide polymorphism (472G/A=V158M) in the coding region of the catechol-O-methyl-transferase (COMT) gene in 115 patients with panic disorder and age- and sex-matched controls. Association analysis revealed a significant excess of the more active COMT allele (4726 = V158) in patients with panic disorder (p=0.04), particularly in female patients (p=0.01), but not in male patients (p=1.0). The assessment of a possible interaction of the COMT polymorphism with a previously reported functional 30-by VNTR in the monoamine oxidase A promoter (MAOA-LPR) in female patients did not yield significant results. Our data support a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women. |
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Language
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English
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Source (journal)
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International journal of neuropsychopharmacology. - Cambridge
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Publication
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Cambridge
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2004
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ISSN
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1461-1457
1469-5111
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DOI
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10.1017/S146114570400416X
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Volume/pages
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7
:2
(2004)
, p. 183-188
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ISI
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000221982600011
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Full text (Publisher's DOI)
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