Title
Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in womenAssociation of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Faculteit Geneeskunde
Publication type
article
Publication
Cambridge,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
International journal of neuropsychopharmacology. - Cambridge
Volume/pages
7(2004):2, p. 183-188
ISSN
1461-1457
ISI
000221982600011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Panic disorder is an anxiety disorder with an estimated heritability of up to 48%. Pharmacological and genetic studies suggest that genes coding for proteins involved in the catecholaminergic system might be relevant for the pathogenesis of the disease. In the present study, we genotyped a single nucleotide polymorphism (472G/A=V158M) in the coding region of the catechol-O-methyl-transferase (COMT) gene in 115 patients with panic disorder and age- and sex-matched controls. Association analysis revealed a significant excess of the more active COMT allele (4726 = V158) in patients with panic disorder (p=0.04), particularly in female patients (p=0.01), but not in male patients (p=1.0). The assessment of a possible interaction of the COMT polymorphism with a previously reported functional 30-by VNTR in the monoamine oxidase A promoter (MAOA-LPR) in female patients did not yield significant results. Our data support a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women.
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