Title
Association of a functional -1019C > G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia Association of a functional -1019C > G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Cambridge ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
International journal of neuropsychopharmacology. - Cambridge
Volume/pages
7(2004) :2 , p. 189-192
ISSN
1461-1457
ISI
000221982600012
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Panic disorder is a common anxiety disorder which frequently co-occurs with agoraphobia. A functional promoter polymorphism in the serotonin receptor 1A (5-HTIA) gene has been found to be associated with major depression as well as anxiety- and depression-related personality traits. We investigated a possible association between this 5-HT1A gene promoter polymorphism and panic disorder by genotyping the -1019C>G single nucleotide polymorphism in 134 panic-disorder patients with and without agoraphobia and matched 134 controls. In our sample no significant evidence of allelic association in the combined panic-disorder group was found. However, our results show a significant association with the G allele in patients with panic disorder with agoraphobia (p=0.03, n=101). In conclusion, our findings do not support a major contribution of this polymorphism to the pathogenesis of panic disorder, but provide evidence for a possible role in the subgroup with agoraphobia.
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