Publication
Title
Effects of volatile anesthetics on elastic stiffness in isometrically contracting ferret ventricular myocardium
Author
Abstract
The effects of halothane, isoflurane, and sevoflurane on elastic stiffness, which reflects the degree of cross-bridge attachment, were studied in intact cardiac muscle. Electrically stimulated (0.25 Hz, 25 degreesC), isometrically twitching right ventricular ferret papillary muscles (n = 15) at optimal length (L-max) were subjected to sinusoidal length oscillations (40 Hz, 0.25-0.50% of L-max peak to peak). The amplitude and phase relationship with the resulting force oscillations was decomposed into elastic and viscous components of total stiffness in real time. Increasing extracellular Ca2+ concentration in the presence of anesthetics to produce peak force equal to control increased elastic stiffness during relaxation, which suggests a direct effect of halothane and sevoflurane on cross bridges.
Language
English
Source (journal)
Journal of applied physiology / American Physiological Society. - Washington, D.C.
Publication
Washington, D.C. : 2002
ISSN
8750-7587
Volume/pages
92:6(2002), p. 2491-2500
ISI
000175739200034
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 10.06.2017
To cite this reference