Title
Effects of volatile anesthetics on elastic stiffness in isometrically contracting ferret ventricular myocardium Effects of volatile anesthetics on elastic stiffness in isometrically contracting ferret ventricular myocardium
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Washington, D.C. ,
Subject
Sociology
Economics
Human medicine
Source (journal)
Journal of applied physiology / American Physiological Society. - Washington, D.C.
Volume/pages
92(2002) :6 , p. 2491-2500
ISSN
8750-7587
ISI
000175739200034
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The effects of halothane, isoflurane, and sevoflurane on elastic stiffness, which reflects the degree of cross-bridge attachment, were studied in intact cardiac muscle. Electrically stimulated (0.25 Hz, 25 degreesC), isometrically twitching right ventricular ferret papillary muscles (n = 15) at optimal length (L-max) were subjected to sinusoidal length oscillations (40 Hz, 0.25-0.50% of L-max peak to peak). The amplitude and phase relationship with the resulting force oscillations was decomposed into elastic and viscous components of total stiffness in real time. Increasing extracellular Ca2+ concentration in the presence of anesthetics to produce peak force equal to control increased elastic stiffness during relaxation, which suggests a direct effect of halothane and sevoflurane on cross bridges.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/1b7a36/5994.pdf
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