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Title
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Effects of volatile anesthetics on elastic stiffness in isometrically contracting ferret ventricular myocardium
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Author
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Abstract
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| The effects of halothane, isoflurane, and sevoflurane on elastic stiffness, which reflects the degree of cross-bridge attachment, were studied in intact cardiac muscle. Electrically stimulated (0.25 Hz, 25 degreesC), isometrically twitching right ventricular ferret papillary muscles (n = 15) at optimal length (L-max) were subjected to sinusoidal length oscillations (40 Hz, 0.25-0.50% of L-max peak to peak). The amplitude and phase relationship with the resulting force oscillations was decomposed into elastic and viscous components of total stiffness in real time. Increasing extracellular Ca2+ concentration in the presence of anesthetics to produce peak force equal to control increased elastic stiffness during relaxation, which suggests a direct effect of halothane and sevoflurane on cross bridges. |
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Language
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English
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Source (journal)
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Journal of applied physiology / American Physiological Society. - Washington, D.C.
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Publication
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Washington, D.C.
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2002
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ISSN
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8750-7587
[print]
1522-1601
[online]
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DOI
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10.1152/JAPPLPHYSIOL.00841.2001
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Volume/pages
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92
:6
(2002)
, p. 2491-2500
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ISI
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000175739200034
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Full text (Publisher's DOI)
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Full text (open access)
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