Publication
Title
Effects of volatile anesthetics on stiffness of mammalian ventricular muscle
Author
Abstract
To assess the effects of halothane, isoflurane, and sevoflurane on cross bridges in intact cardiac muscle, electrically stimulated (0.25 Hz, 25 degreesC) right ventricular ferret papillary muscles (n = 14) were subjected to sinusoidal load oscillations (37-182 Hz, 0.2-0.5 mN peak to peak) at the instantaneous self-resonant frequency of the muscle-lever system. At resonance, stiffness is proportional to in * omega (2) (where in is equivalent moving mass and omega is angular frequency). Dynamic stiffness was derived by relating total stiffness to values of passive stiffness at each length during shortening and lengthening. Shortening amplitude and dynamic stiffness were decreased by halothane > isoflurane greater than or equal to sevoflurane. At equal peak shortening, dynamic stiffness was higher in halothane or isoflurane in high extracellular Ca2+ concentration than in control. Halothane and isoflurane increased passive stiffness. The decrease in dynamic stiffness and shortening results in part from direct effects of volatile anesthetics at the level of cross bridges. The increase in passive stiffness caused by halothane and isoflurane may reflect an effect on weakly bound cross bridges and/or an effect on passive elastic elements.
Language
English
Source (journal)
Journal of applied physiology / American Physiological Society. - Washington, D.C.
Source (book)
75th Clinical and Scientific Congress of the, International-Anesthesia-Research-Society, MAR 16-20, 2001, FT LAUDERDALE, FLORIDA
Publication
Bethesda : Amer physiological soc, 2001
ISSN
8750-7587
Volume/pages
91:4(2001), p. 1563-1573
ISI
000171128300010
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 22.09.2017
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