Title
Effect of intensive magnesium supplementation on the in vitro oxidizability of LDL and VLDL in Mg-depleted type 1 diabetic patients Effect of intensive magnesium supplementation on the in vitro oxidizability of LDL and VLDL in Mg-depleted type 1 diabetic patients
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London ,
Subject
Chemistry
Biology
Human medicine
Source (journal)
Magnesium research : official organ of the International Society for the Development of Research on Magnesium (SDRM) / Society for the Development of Research on Magnesium (SDRM) - London
Volume/pages
11(1998) :3 , p. 179-182
ISSN
0953-1424
ISI
000076520100005
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Type 1 diabetic patients with low RBC-MG have an increased in vitro oxidizability of LDL and VLDL as compared to matched diabetic controls with normal RBC-MG. In this study the effect of a 10 week intensive oral + i.v. supplementation with Mg was studied in 11 depleted type 1 patients under stable metabolic control. Despite the significant increase of erythrocyte Mg and the higher body stores demonstrated by the Mg retention test, no significant decrease of the oxidizability could be demonstrated after supplementation. Persistent Mg loss in the presence of peripheral hyperinsulinaemia, insufficient and/or too short supplementation and decreased antioxidant defence could be the reasons for this negative result.
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