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Achievement of optimal average relative dose intensity and correlation with survival in diffuse large B-cell lymphoma patients treated with CHOP
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| Abstract |
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| The treatment of diffuse large B-cell lymphoma with chemotherapy was retrospectively evaluated in 348 patients who had received at least three cycles of CHOP ( cyclophosphamide, doxorubicin, vincristine, and prednisone)like, ACVBP ( doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone)-like or CHVmP-BV ( cyclophosphamide, hydroxorubicin, Vm-26, prednisone, vincristine and bleomycin) treatment in Belgium between 1995 and 2000. In our sample, the proportion who received each of the three regimens was 78.4, 16.4, and 5.2%, respectively. Of those prescribed CHOP-like regimens, 15% received 80% average relative dose intensity (ARDI). In 210 patients treated with CHOP-21 (77% of the CHOP-like group), median survival was 7.08 years in those who received > 90% of the ARDI, significantly longer than in those who received <=; 90% of the ARDI (p= 0.002). Dose reductions and/or delays, mainly due to hematological toxicities, resulted in a reduction in treatment intensity. These data indicate that patient outcome is improved when the intensity of chemotherapy treatment is optimal. |
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English
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Annals of hematology. - Berlin | |
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Berlin : 2008
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0939-5555
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87:4(2008), p. 277-283
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000254176400004
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