Publication
Title
Achievement of optimal average relative dose intensity and correlation with survival in diffuse large B-cell lymphoma patients treated with CHOP
Author
Abstract
The treatment of diffuse large B-cell lymphoma with chemotherapy was retrospectively evaluated in 348 patients who had received at least three cycles of CHOP ( cyclophosphamide, doxorubicin, vincristine, and prednisone)like, ACVBP ( doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone)-like or CHVmP-BV ( cyclophosphamide, hydroxorubicin, Vm-26, prednisone, vincristine and bleomycin) treatment in Belgium between 1995 and 2000. In our sample, the proportion who received each of the three regimens was 78.4, 16.4, and 5.2%, respectively. Of those prescribed CHOP-like regimens, 15% received 80% average relative dose intensity (ARDI). In 210 patients treated with CHOP-21 (77% of the CHOP-like group), median survival was 7.08 years in those who received > 90% of the ARDI, significantly longer than in those who received <=; 90% of the ARDI (p= 0.002). Dose reductions and/or delays, mainly due to hematological toxicities, resulted in a reduction in treatment intensity. These data indicate that patient outcome is improved when the intensity of chemotherapy treatment is optimal.
Language
English
Source (journal)
Annals of hematology. - Berlin
Publication
Berlin : 2008
ISSN
0939-5555
Volume/pages
87:4(2008), p. 277-283
ISI
000254176400004
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 14.09.2017
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