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Title
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Origin of threshold behaviour in psoriatic skin
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Author
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Abstract
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| The mechanisms that lead to the psoriatic morphology are not fully elucidated. Several lines of evidence suggest that the positive feedback between keratinocytes and immunocytes plays a key role in the development of the lesions. On the other hand, little information is available on the negative regulatory controls that maintain a new homoeostasis level in psoriatic skin. We suggest here that the interplay of these two contrary feedbacks is likely to entail a hysteresis effect and that psoriasis is likely to be interpreted as a critical phenomenon characterized by a catastrophic shift of the skin from a normal to a hyperplastic state. Copyright (c) 2008 S. Karger AG, Basel |
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Language
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English
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Source (journal)
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Dermatology. - Basel
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Publication
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Basel
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2008
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ISSN
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1018-8665
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DOI
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10.1159/000151354
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Volume/pages
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217
:4
(2008)
, p. 295-298
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ISI
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000260229300001
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Full text (Publisher's DOI)
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