Publication
Title
Origin of threshold behaviour in psoriatic skin
Author
Abstract
The mechanisms that lead to the psoriatic morphology are not fully elucidated. Several lines of evidence suggest that the positive feedback between keratinocytes and immunocytes plays a key role in the development of the lesions. On the other hand, little information is available on the negative regulatory controls that maintain a new homoeostasis level in psoriatic skin. We suggest here that the interplay of these two contrary feedbacks is likely to entail a hysteresis effect and that psoriasis is likely to be interpreted as a critical phenomenon characterized by a catastrophic shift of the skin from a normal to a hyperplastic state. Copyright (c) 2008 S. Karger AG, Basel
Language
English
Source (journal)
Dermatology. - Basel
Publication
Basel : 2008
ISSN
1018-8665
Volume/pages
217:4(2008), p. 295-298
ISI
000260229300001
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 07.06.2017
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