Title
Classification of sporadic Creutzfeldt-Jakob disease based on clinical and neuropathological characteristics Classification of sporadic Creutzfeldt-Jakob disease based on clinical and neuropathological characteristics
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Roma ,
Subject
Human medicine
Source (journal)
European journal of epidemiology. - Roma
Volume/pages
22(2007) :7 , p. 457-465
ISSN
0393-2990
ISI
000248762700006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disease of unknown cause. Patients are usually aged between 50 and 75 and typical clinical features include rapidly progressive dementia associated with myoclonus and a characteristic electroencephalographic pattern. Neuropathological examination reveals cortical spongiform change, hence the term 'spongiform encephalopathy'. Several statistical techniques were applied to classify patients with sporadic CJD (sCJD), based on clinical and neuropathological investigation. We focus on the classification of neuropathologically confirmed sCJD patients. In order to obtain a classification rule that correctly classifies this type of patients and at the same time controls the overall error rate, we apply several classification techniques, which in general, produce comparable results. The boosting method produces the best results and the variable 14-3-3 protein in cerebrospinal fluid plays the most important role in the prediction of neuropathologically confirmed sCJD.
E-info
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