Publication
Title
Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application
Author
Abstract
The cytotoxicity and physical properties of various submicron O/W emulsions and solid lipid nanoparticles for dermal applications were investigated. Droplet size and zetapotential of submicron emulsions depended on the composition of the cosurfactant blend used. The viability of J774 macrophages, mouse 3T3 fibroblasts and HaCaT keratinocytes was significantly reduced in the presence of stearylantine. Nanoparticles consisting of stearic acid or different kinds of adeps solidus could be manufactured when formulated with lecithin, sodium taurocholate, polysorbate 80 and stearylamine. Survival of macrophages was highly affected by stearic acid and stearylamine. In general a viability of more than 90% was observed when semi-synthetic glycerides or hard fat was employed to formulate nanoparticles. (c) 2007 Elsevier B.V. All rights reserved.
Language
English
Source (journal)
International journal of pharmaceutics. - Amsterdam
Publication
Amsterdam : 2007
ISSN
0378-5173
Volume/pages
337:1-2(2007), p. 291-298
ISI
000247355800034
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 25.07.2017
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