Title
Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal applicationCytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Research group
Laboratory of Pharmaceutical Technology and Biopharmacy
Publication type
article
Publication
Amsterdam,
Subject
Pharmacology. Therapy
Source (journal)
International journal of pharmaceutics. - Amsterdam
Volume/pages
337(2007):1-2, p. 291-298
ISSN
0378-5173
ISI
000247355800034
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The cytotoxicity and physical properties of various submicron O/W emulsions and solid lipid nanoparticles for dermal applications were investigated. Droplet size and zetapotential of submicron emulsions depended on the composition of the cosurfactant blend used. The viability of J774 macrophages, mouse 3T3 fibroblasts and HaCaT keratinocytes was significantly reduced in the presence of stearylantine. Nanoparticles consisting of stearic acid or different kinds of adeps solidus could be manufactured when formulated with lecithin, sodium taurocholate, polysorbate 80 and stearylamine. Survival of macrophages was highly affected by stearic acid and stearylamine. In general a viability of more than 90% was observed when semi-synthetic glycerides or hard fat was employed to formulate nanoparticles. (c) 2007 Elsevier B.V. All rights reserved.
E-info
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