Title
Increased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathyIncreased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathy
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Faculteit Geneeskunde
Antwerp Surgical Training, Anatomy and Research Centre (ASTARC)
Publication type
article
Publication
Oxford,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
Life sciences. - Oxford
Volume/pages
77(2005):4, p. 414-422
ISSN
0024-3205
ISI
000229419100005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
NMDA receptors are involved in the modulation of neuropathic pain behavior and central sensitization. In vivo, this is mostly demonstrated by the use of specific antagonists Such as MK801. Because studies evaluating the direct impact of spinal NMDA in neuropathic pain models are lacking, we performed a series of experiments to study the role of spinal NMDA injection on existing cold allodynia, as a measurement of neuropathic pain behavior in rodents. Intrathecal. injection of NMDA resulted in an enhanced neuropathic pain behavior in CCI rats on a cold plate. The activity was present from a dose of 5 ng/rat onward and Could selectively be reversed by intraperitoneal injections of doses of >= 0.01 mg/kg MK801. These results support the regulatory role of NMDA receptors in the hypersensitivity to cold observed in neuropathic pain behavior in rodents. (c) 2005 Elsevier Inc. All rights reserved.
E-info
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