Publication
Title
Increased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathy
Author
Abstract
NMDA receptors are involved in the modulation of neuropathic pain behavior and central sensitization. In vivo, this is mostly demonstrated by the use of specific antagonists Such as MK801. Because studies evaluating the direct impact of spinal NMDA in neuropathic pain models are lacking, we performed a series of experiments to study the role of spinal NMDA injection on existing cold allodynia, as a measurement of neuropathic pain behavior in rodents. Intrathecal. injection of NMDA resulted in an enhanced neuropathic pain behavior in CCI rats on a cold plate. The activity was present from a dose of 5 ng/rat onward and Could selectively be reversed by intraperitoneal injections of doses of >= 0.01 mg/kg MK801. These results support the regulatory role of NMDA receptors in the hypersensitivity to cold observed in neuropathic pain behavior in rodents. (c) 2005 Elsevier Inc. All rights reserved.
Language
English
Source (journal)
Life sciences. - Oxford
Publication
Oxford : 2005
ISSN
0024-3205
0300-9653
Volume/pages
77:4(2005), p. 414-422
ISI
000229419100005
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.01.2013
Last edited 14.11.2017
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